Balancing selection shapes population differentiation of MHC genes in wild golden snub-nosed monkeys

نویسندگان

چکیده

Abstract Small and isolated populations face several intrinsic risks, such as genetic drift, inbreeding depression reduced gene flow, patterns of diversity differentiation have become an important focus conservation genetics research. The golden snub-nosed monkey Rhinopithecus roxellana, endangered species endemic to China, has experienced rapid reduction in population size severe fragmentation over the past few decades. We measured using both neutral microsatellites adaptive major histocompatibility complex (MHC) genes two R. roxellana (DPY GNG) distributed on northern southern slopes Qinling Mountains, respectively. Eight MHC linked haplotypes formed by five DQA1 alleles, DQB1 DRB1 alleles four DRB2 were detected populations. larger GNG showed higher variation for than smaller DPY population, suggesting effect drift variation. Genetic index (FST) outlier analyses, principal coordinate analysis (PCoA) inferred structure lower variations microsatellites, that pathogen-mediated balancing selection, rather local adaptation, homogenized This study indicates selection may shape small fragmented

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ژورنال

عنوان ژورنال: Current Zoology

سال: 2023

ISSN: ['2058-5888', '1674-5507', '2396-9814']

DOI: https://doi.org/10.1093/cz/zoad043